Below is the Program at a glance.
| Sunday, August 29th 2010 | |
| 12:00 - 2:00 | Registration |
| 2:20-2:30 | Opening remarks, Debbie Hay and Kerry Loomes |
| 2:30-3:30 | SESSION I: OPENING PLENARY, Garth Cooper, University of Auckland |
| Amylin and diabetes: what have we learned during the past 25 years? | |
| Chaired by Kerry Loomes | |
| 3:30-4:00 | Coffee Break - Gallery |
| 4:00-5:30 | SESSION II: NEW PERSPECTIVES AND CLINICAL APPLICATIONS OF AMYLIN |
| Thomas Lutz, University of Zurich | |
| Amylin and the control of energy metabolism – from physiology to clinical application | |
| Arpad Dobolyi, Hungarian Academy of Sciences and Semmelweis University Budapest | |
| Central amylin expression and its potential involvement in maternal regulations | |
| Jonathan Roth, Amylin | |
| Weighing in on Synergy: Neurohormonal Combinations for Obesity | |
| Chaired by David Poyner | |
| 5:30-6:00 | Break |
| 6:00-7:30 | Welcome reception - Galaxy ballroom 2 & 3; drinks and light food |
| Own arrangements for dinner | |
| Monday 30th August 2010 | |
| 9:00-10:00 | SESSION III: PLENARY, Susan Brain, Kings College London |
| CGRP: teasing out pivotal vascular mechanisms that operate in vivo. | |
| Chaired by Andy Russo | |
| 10:00-10:30 | Coffee break |
| 10:30-12.00 | SESSION IV: CGRP - THERAPEUTIC AVENUES BEYOND MIGRAINE? |
| Ian Dickerson, University of Rochester | |
| Seeing the Light: Fluorescent CGRP and Tumor Proliferation | |
| Kerry Loomes, University of Auckland | |
| Mice Lacking the Neuropeptide a-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity | |
| Andy Russo, University of Iowa | |
| Neuronal RAMP1 promotes migraine-like behavior and energy expenditure in mice | |
| Chaired by Susan Brain | |
| 12:00-1.00pm | Lunch and Posters - Gallery and Galaxy ballroom 2 & 3 |
| 1:00-2:30 | SESSION V: NOVEL FUNCTIONS OF THE ADRENOMEDULLIN PEPTIDES |
| Yoshio Takei, University of Tokyo | |
| Novel adrenomedullins and possible presence of novel receptors in the CGRP family | |
| Takayuki Shindo, Shinshu University | |
| RAMP2 is the Key Determinant of the Vascular Functions of Adrenomedullin | |
| Alfredo Martinez, Center for Biomedical Research of La Rioja | |
| Consequences of the conditional elimination of adrenomedullin from the mouse brain | |
| Chaired by Ian Dickerson | |
| 2:30-3:00 | Coffee break - Gallery |
| 3:00-4:30 | SESSION VI: HOT TOPICS IN THE CGRP FAMILY OF PEPTIDES (short orals selected from abstracts) |
| Sheau Yu Teddy Hsu, Stanford University School of Medicine | |
| A crucial role for intrafollicular intermedin signaling in oocyte-cumulus cell interactions | |
| Leonid Nikitenko, University College London | |
| Adrenomedullin deficiency causes impaired function of both blood and lymphatic subcutaneous vessels in acute post-surgical conditions | |
| Christopher Walker, University of Auckland | |
| Pancreatic over-expression of human amylin elevates energy expenditure in transgenic mice | |
| James Barwell, Aston University | |
| The importance of ECL1 and associated transmembrane domains of the CLR in facilitating CGRP receptor activation | |
| Maho Ogoshi, Okayama University | |
| Cardiovascular and osmoregulatory effects of homologous adrenomedullins in eels | |
| Anette Sams, Novo Nordisk | |
| CGRP analogues induce exercise-like pharmacology and may be used for the treatment of hypertensive type 2 diabetes | |
| Chaired by Chris Charles | |
| 4:30-5:00 | Break |
| 5:00-7:00 | Poster session - with short oral presentations from each poster presenter; drinks and light food |
| Own arrangements for dinner | |
| Tuesday 31st August 2010 | |
| 9:00-10:00am | SESSION VII: PLENARY, Kenji Kuwasako |
| Interaction between receptor activity-modifying proteins (RAMPs) and G-protein-coupled receptors and the function of the C-terminal tail of calcitonin receptor-like receptor in complex with RAMP2 | |
| Chaired by Patrick Sexton | |
| 10:00-10:30 | Coffee Break - Gallery |
| 10:30-12:30 | SESSION VIII: NEW INSIGHTS INTO THE STRUCTURE AND FUNCTION OF CGRP-FAMILY RECEPTORS |
| Patrick Sexton, Monash University | |
| Polymorphism dependent signaling bias at the human calcitonin receptor | |
| Laurence Miller, Mayo Clinic | |
| Understanding calcitonin receptor ligand binding and function | |
| David Poyner, Aston University | |
| The role of the extracellular loops of CLR in binding CGRP | |
| Chaired by Chris Salvatore | |
| IUPHAR session (David Poyner) | |
| The advantages and disadvantages of the current receptor and peptide nomenclature | |
| 12:30-1.15pm | Lunch and Posters - Gallery and Galaxy ballroom 2 &3 |
| 1:15-2:45 | SESSION IX: ANTAGONISTS FOR CGRP-FAMILY RECEPTORS |
| Debbie Hay, University of Auckland | |
| The quest for adrenomedullin receptor antagonists | |
| Chris Salvatore, Merck | |
| Unraveling the CGRP receptor puzzle - How and where do antagonists act to relieve migraine headache? | |
| Jonathan Moore, Vertex | |
| Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism | |
| Chaired by Debbie Hay | |
| 2:45-3:15 | Coffee Break - Gallery |
| 3:15-4:50 | SESSION X: CLINICAL POTENTIAL OF CGRP-FAMILY PEPTIDES |
| Bodil-Cecilie Søndergaard, Nordic Bioscience | |
| Mice over-expressing salmon calcitonin have strongly attenuated bone and cartilage changes after destabilization of the medial meniscus | |
| Jan de Hoon, University Hospitals Leuven | |
| CGRP antagonists: the challenges of early clinical drug development | |
| Chris Charles, Christchurch School of Medicine | |
| Adrenomedullins: Therapeutic Potential in Cardiovascular Disease | |
| Chaired by Teddy Hsu | |
| Closing remarks; next meeting? | |
| 5:30-late | Conference dinner |